QUANTIFICATION OF LOCAL CIRCULATION WITH OCT ANGIOGRAPHY

摘要

Impaired intraocular blood flow within vascular beds in the human eye is associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions. A method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.

主权项

1. A method for quantitatively measuring blood flow in an ocular vascular bed, said method comprising:
selecting an ocular vascular bed from which to quantitatively measure blood flow; scanning said ocular vascular bed to obtain M-B scans of OCT spectrum therefrom; splitting the M-B scans of OCT spectrum into M spectral bands; and determining a quantitative measurement of blood flow from the M spectral bands.