| 摘要 |
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like. |
| 主权项 |
1. A compound having the structure of Formula (II), or a pharmaceutically acceptable salt thereof, wherein, R1 is hydrogen or alkyl; G is X—R2 or X1-alkyl, wherein X is a bond, alkylene, alkylene-O—, —C(O)—, —C(O)—NH—, —NH—, —NH—C(O)—, —O—, —S—, or —SO2—; R2 is selected from carbocyclyl, heterocyclyl, aryl, or heteroaryl; X1 is a bond, —C(O)—, —C(O)—NH—, —NH—, —NH—C(O)—, —O—, —S—, or —SO2—; and R3 is hydrogen, halogen or alkyl. |
