PRODUCTION METHOD OF KETOMALONIC ACID COMPOUND

摘要

Provided is a method for producing an industrially useful ketomalonic acid compound such as ketomalinic acid diesters, or a hydrate thereof, by a method more favorable from an economic and environmental standpoint and from a safety standpoint. The present invention relates to a method involving reacting a malonic acid compound represented by general formula (1);;(in the formula, The each Rs indicate an alkyl group, a cycloalkyl group, etc.) with chlorine dioxide to produce a ketomalonic acid compound represented by the general formula (2);;(in the formula, R has the same meaning as above), or a hydrate thereof.

主权项

1. A method of producing a ketomalonic acid compound represented by the general formula (2) (wherein Rs may be the same or different from each other, and each represents a hydrogen atom, an alkyl group which optionally has substituent(s), a cycloalkyl group which optionally has substituent(s), an aromatic hydrocarbon group which optionally has substituent(s), or an aromatic heterocyclic group which optionally has substituent(s), and the two Rs may bind to each other to form a ring) or a hydrate thereof by reacting a malonic acid compound represented by the general formula (1) (wherein R is the same as described above) with chlorine dioxide.