| 发明名称 |
RNA BASED METHOD TO OBTAIN STABLY INTEGRATED RETROVIRAL VECTORS |
| 摘要 |
The present invention relates to viral transformation method, particularly foamy virus-mediated transformation method. The present invention relates to the transfer of transgene into cells by the safe and efficient transfer of RNA encoding foamy components. The present invention has therefore therapeutic interest, especially in the field of gene therapy. |
| 申请公布号 |
US2016222410(A1) |
申请公布日期 |
2016.08.04 |
| 申请号 |
US201414915434 |
申请日期 |
2014.09.02 |
| 申请人 |
CELLECTIS |
发明人 |
SCHARENBERG Andrew;SMITH Julianne;GALETTO Roman |
| 分类号 |
C12N15/86;C12N7/00 |
主分类号 |
C12N15/86 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for integrating a transgene within the genome of a cell comprising:
(a) Providing at least one RNA comprising: (i) sequence encoding foamy virus Gag protein, (ii) sequence encoding foamy virus Pol protein; (iii) Foamy Virus genomic sequence and a transgene; (b) Introducing said RNA into a cell. |
| 地址 |
Paris FR |
