METHODS FOR PREDICTING HEPATOTOXICITY

摘要

Methods of predicting hepatotoxicity of a compound by providing an in vitro hepatocyte culture system capable of expressing a panel of genes, wherein the culture may be incubated with the compound or compounds to be screened and the expression level of the panel of genes measured is described herein. By comparing the expression level of the panel of genes in the culture system exposed to the compound(s) being screened with the gene expression of the same panel of genes in a control culture system, hepatotoxicity of the compound(s) is able to be predicted.