PROCESS FOR THE PREPARATION OF 3,4-DIHYDRO-2H-THIEN[3,2-E]-1,2-THIAZIN-4-OL 1, 1-DIOXIDE DERIVATIVES AND INTERMEDIATES

摘要

The present invention relates to a process for the preparation of Brinzolamide, or 2H-thieno[3,2-e]-1,2-thiazin-6-sulfonamide, 4-(ethyl amino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4R)-via intermediates 2,3-dihydro-4H-thieno[3,2-e]-1,2-thiazin-4-ones, 1,1-dioxide. Further objects of the present invention are the intermediates mentioned above and other intermediates of the synthesis.