RECOMBINANT TUMOR SPECIFIC ANTIBODY AND USE THEREOF

摘要

The invention provides a family of antibodies that specifically bind the hum an epithelial cell adhesion molecule. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies, when coupled to the appropriate moiety, may be used in the diagnosis, prognosis and treatmen t of cancer.