摘要 |
This invention is based upon the application of compatible solutes to immobilized biological materials or to immobilize in order to improve the technical performance using the same, namely nucleic acid and proteins or biosensors micronets. The above mentioned compatible solutes are selected from a group that includes Mannosylglycerate (MG) and its 3 derivatives manno- sylglyceramide (MGA), -mannosylglycerol (MGOH), and mannosyl-lactate (MGLac), 1,1-di-glycerol phosphate (DGP), ectoin, hydroxyectoin, and or derivatives or combinations thereof. The improved performance of the above mentioned techniques might be due to: a better state of preservation of the material to be immobilized, increasing the life expectancy of the material, and/or decreasing the storage and/or transport requirements, a more efficient and uniform deposition of the material on the support, more efficiency and/or specificity of hybridation of the marked material, all this originating an increase of the signal-to-noise ratio. |
申请人 |
STAB VIDA, INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS, LDA;BITOP AG;PEREIRA DE OLIVEIRA DA SILVA SANTOS, JORGE MIGUEL;MACHADO, CATIA;VARELA RAPOSO, ANA CATARINA;VOLINIA, STEFANO;MASCELLANI, NICOLETTA;SETFORD, STEVEN JOHN;LOOSE, ELISABETH;MAYCOCK, CHRISTOPHER DAVID;MENDES BORDALO VENTURA CENTENO LIMA, MARIA RITA;LAMOSA ANTONIO, PEDRO;SEQUEIRA LOPES, ISABEL;SANTOS, HELENA;DE LEAO E FLORES, ALCINO ORFEU |
发明人 |
PEREIRA DE OLIVEIRA DA SILVA SANTOS, JORGE MIGUEL;MACHADO, CATIA;VARELA RAPOSO, ANA CATARINA;VOLINIA, STEFANO;MASCELLANI, NICOLETTA;SETFORD, STEVEN JOHN;LOOSE, ELISABETH;MAYCOCK, CHRISTOPHER DAVID;MENDES BORDALO VENTURA CENTENO LIMA, MARIA RITA;LAMOSA ANTONIO, PEDRO;SEQUEIRA LOPES, ISABEL;SANTOS, HELENA;DE LEAO E FLORES, ALCINO ORFEU |