发明名称 |
PEGYLATED MUTATED CLOSTRIDIUM BOTULINUM TOXIN |
摘要 |
The invention relates to a modified botulinum toxin which has a naturally occurring heavy chain and a modified light chain. The invention is characterized in that the modification of the light chain is that it comprises (i) on its N terminus an extension of the chain which has the structure -(C)<SUB>n</SUB>-(tag)<SUB>m</SUB>-(X)<SUB>l</SUB>- in the direction from the N terminus to the C terminus, C representing a cysteine group, tag representing any tag and X representing a group of any naturally occurring amino acid, n being an integer from 1 to 50, m being 0 or 1 and l being 0 or an integer from 1 to 50, and (ii) that at least one of the cystein groups in the extension of the chain is coupled to at least one chain PEG. |
申请公布号 |
WO2007104567(A2) |
申请公布日期 |
2007.09.20 |
申请号 |
WO2007EP02296 |
申请日期 |
2007.03.15 |
申请人 |
BIOTECON THERAPEUTICS GMBH;FREVERT, JUERGEN;SPECHT, VOLKER |
发明人 |
FREVERT, JUERGEN;SPECHT, VOLKER |
分类号 |
C07K14/33;A61K38/16 |
主分类号 |
C07K14/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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