USE OF PROTEASES FOR GLUTEN INTOLERANCE

摘要

PROBLEM TO BE SOLVED: To provide enzyme compositions.SOLUTION: The invention provides an enzyme cocktail capable of cleaving a gluten oligopeptide comprising a composition selected from the group consisting of: GDEP; GDEP-LGG; GDEP-M; GDEP-LNA; GDEP-2A; GDEP-AH; papain; aorsin, an acidic serine protease polypeptide having an amino acid sequence being about 80% homology to aorsin or a fragment thereof CPY; an enzyme having an amino acid sequence being about 80% homology to CPY or a fragment thereof; and a preparation from Penicillium citrinum. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.SELECTED DRAWING: None