MOBILE PHASE CONTROLLER FOR SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS

摘要

The present disclosure relates to an apparatus for regulating the average mobile phase density or pressure in a carbon dioxide based separation system. The apparatus includes a controller, a set of pressure or density sensors and a set of instructions capable of determining the pressure drop across a column and adjusting at least one system component or parameter to achieve a pre-determined average mobile phase density or pressure in the system.

主权项

1. An apparatus for regulating the average mobile phase density or pressure in a carbon dioxide based separation system comprising:
a controller; a first sensor and a second sensor both in signal communication with the controller, wherein the first sensor is capable of measuring a first mobile phase density or pressure in the system and the second sensor is capable of measuring a second mobile phase density or pressure in the system; and a set of instructions utilized by the controller, wherein the controller is capable of averaging the first and the second mobile phase density or pressure measurements to determine an average mobile phase density or pressure value and adjusting at least one system component or parameter to achieve a pre-determined average mobile phase density or pressure in the system in response to the average mobile phase density or pressure value.