CANCER SPECIFIC ANTIGEN-BINDING PROTEINS

摘要

The present invention relates to antigen-binding proteins, and antigen-binding fragments thereof that binds to clathrin heavy chain 1 (CHC1) on the surface of cancer stem cells. The present invention also relates to compositions comprising the antigen-binding protein, and antigen-binding fragments thereof and use of these antigen-binding protein, and antigen-5 binding fragments thereof as well as methods for detecting cancer in a subject comprising the step of contacting a sample with the antigen-binding protein, and antigen-binding fragments thereof of the invention. Methods of treating cancer and kits for use in the methods of the invention are also described.