ANTI-KRS MONOCLONAL ANTIBODY AND USE THEREOF

摘要

The present invention relates to an anti-lysyl-tRNA synthetase (KRS) antibody selectively binding to KRS, and a use thereof and, more specifically, to an antibody binding to human KRS or a fragment thereof, a method for producing the same, and a composition containing the same for diagnosing cancer, autoimmune diseases or inflammatory diseases. The antibody or fragment thereof of the present invention specifically binds to human KRS, and enables KRS detection and inhibition due to the absence of cross-linkage reactivity with the other proteins including the same ARS family, and thus the antibody or fragment thereof can be used to detect KRS and diagnose KRS-related diseases, i.e., cancer, autoimmune diseases or inflammatory diseases.

主权项

1. An antibody or fragment thereof that binds to human lysyl-tRNA Synthetase (KRS), the antibody comprising:
an antibody light chain variable region (VL) comprising complementarity-determining region (CDR) L1 including the amino acid sequence represented by SEQ ID NO: 1, complementarity-determining region (CDR) L2 including the amino acid sequence represented by SEQ ID NO: 2, and complementarity-determining region (CDR) L3 including the amino acid sequence represented by SEQ ID NO: 3; and an antibody heavy chain variable region (VH) comprising complementarity-determining region (CDR) H1 including the amino acid sequence represented by SEQ ID NO: 4, complementarity-determining region (CDR) H2 including the amino acid sequence represented by SEQ ID NO: 5, and complementarity-determining region (CDR) H3 including the amino acid sequence represented by SEQ ID NO: 6.