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1. A method of treating diseases or disorders related to c-Jun N-terminal kinase (JNK) signaling in a subject, comprising administering to the subject a pharmaceutical composition comprising a chimeric peptide comprising an amino acid sequence having a sequence identity of at least 80% with SEQ ID NO: 11, wherein the diseases or disorders related to JNK signaling in a subject are selected from the group of inflammatory or non-inflammatory diseases selected from the group consisting of:
(a) age-related macular degeneration (AMD) and cataract, (b) eye inflammatory diseases, uveitis, scleritis, corneal surgery, conjunctivitis, non-infectious keratitis, iritis, chorioretinal inflammation, inflammatory diseases damaging the retina of the eye (retinopathy), diabetic retinopathy, arterial hypertension induced hypertensive retinopathy, radiation induced retinopathy, sun-induced solar retinopathy, trauma-induced retinopathy, Purtscher's retinopathy, retinopathy of prematurity (ROP) and hyperviscosity-related retinopathy, (c) Addison's disease, Agammaglobulinemia, Alopecia areata, Amytrophic lateral sclerosis, Antiphospholipid syndrome, Atopic allergy, Autoimmune aplastic anemia, Autoimmune cardiomyopathy, Autoimmune enteropathy, Autoimmune hemolytic anemia, Autoimmune inner ear, disease, Autoimmune lymphoproliferative syndrome, Autoimmune polyendocrine syndrome, Autoimmune progesterone dermatitis, Idiopathic thrombocytopenic purpura, Autoimmune urticaria, Balo concentric sclerosis, Bullous pemphigoid, Castleman's disease, Cicatricial pemphigoid, Cold agglutinin disease, Complement component 2 deficiency associated disease, Cushing's syndrome, Dagos disease, Adiposis dolorosa, Eosinophilic pneumonia, Epidermolysis bullosa acquisita, Hemolytic disease of the newborn, Cryoglobulinemia, Evans syndrome, Fibrodysplasia ossificans progressive, Gastrointestinal pemphigoid, Goodpasture's syndrome, Hashimoto's encephalopathy, Gestational pemphigoid, Hughes-stovin syndrome, Hypogammaglobulinemia, Lambert-eaton myasthenic syndrome, Lichen sclerosus, Morphea, Pityriasis lichenoides et varioliformis acuta, Myasthenia gravis, Narcolepsy, Neuromyotonia, Opsoclonus myoclonus syndrome, Paraneoplastic cerebellar degeneration, Paroxysmal nocturnal hemoglobinuria, Parry-romberg syndrome, Pernicious anemia, POEMS syndrome, Pyoderma gangrenosum, Pure red cell aplasia, Raynaud's phenomenon, Restless legs syndrome, Retroperitoneal fibrosis, Autoimmune polyendocrine syndrome type 2, Stiff person syndrome, Susac's syndrome, Febrile neutrophilic dermatosis, Sydenham's chorea, Thrombocytopenia, and vitiligo, (d) arthritis, juvenile idiopathic arthritis, psoriastic arthritis, rheumatoid arthritis, arthrosis, and osteoarthritis, (e) skin diseases, psoriasis, eczema, dermatitis, acne, mouth ulcers, erythema, lichen plan, sarcoidose, vascularitis, adult linear IgA disease, (f) tauopathies, amyloidoses and prion diseases, (g) polypes, (h) inflammatory diseases of the mouth or the jaw bone, pulpitis, periimplantitis, periodontitis, gingivitis, stomatitis, mucositis, desquamative disorders, and temporomandibular joint disorder, (i) osteonecrosis, (j) encephalomyelitis, acute disseminated encephalomyelitis, spondylitis, ankylosing spondylitis, antisynthetase syndrome, dermatitis, atopic dermatitis or contact dermatitis, hepatitis, autoimmune hepatitis, autoimmune peripheral neuropathy, pancreatitis, autoimmune pancreatitis, Behçet's disease, Bickerstaff's, encephalitis, Blau syndrome, Coeliac disease, Chagas disease, polyneuropathy, chronic inflammatory demyelinating polyneuropathy, osteomyelitis, chronic recurrent multifocal osteomyelitis, Churg-Strauss syndrome, Cogan syndrome, giant-cell arteritis, CREST syndrome, vasculitis, cutaneous small-vessel vasculitis and urticarial vasculitis, dermatitis herpetiformis, dermatomyositis, systemic scleroderma, Dressler's syndrome, drug-induced lupus erythematosus, discoid lupus erythematosus, enthesitis, eosinophilic fasciitis, eosinophilic gastroenteritis, erythema nodosum, Idiopathic pulmonary fibrosis, gastritis, Grave's disease, Guillain-barré syndrome, Hashimoto's thyroiditis, Henoch-Schonlein purpura, Hidradenitis suppurativa, Idiopathic inflammatory demyelinating diseases, myositis, inclusion body myositis, cystitis, interstitial cystitis, Kawasaki disease, Lichen planus, lupoid hepatitis, Majeed syndrome, Ménière's disease, microscopic polyangiitis, mixed connective tissue disease, myelitis, neuromyelitis optica, thyroiditis, Ord's thyroiditis, rheumatism, palindromic rheumatism, Parsonage-Turner syndrome, pemphigus vulgaris, perivenous encephalomyelitis, polyarteritis nodosa, polymyalgia, polymyalgia rheumatica, polymyositis, cirrhosis, primary biliary cirrhosis, cholangitis, primary sclerosing cholangitis, progressive inflammatory neuropathy, Rasmussen's encephalitis, relapsing polychondritis, arthritis, reactive arthritis (Reiter disease) and rheumatoid arthritis, rheumatic fever, sarcoidosis, Schnitzler syndrome, serum sickness, spondyloarthropathy, Takayasu's arteritis, Tolosa-Hunt syndrome, transverse myelitis, and Wegener's granulomatosis, (k) fibrotic diseases and/or disorders, lung fibrotic diseases and/or disorders, heart fibrotic diseases and/or disorders, liver fibrotic diseases and/or disorders, bone marrow fibrotic diseases and/or disorders, mediastinum fibrotic diseases and/or disorders, retroperitoneum fibrotic diseases and/or disorders, skin fibrotic diseases and/or disorders, intestine fibrotic diseases and/or disorders, joint fibrotic diseases and/or disorders, and shoulder fibrosis, (l) kidney diseases and/or disorders, glomerulonephritis, membrano-proliferative glomerulonephritis, mesangio-proliferative glomerulonephritis, rapidly progressive glomerulonephritis, nephrophathies, membranous nephropathy, diabetic nephropathy, nephritis, lupus nephritis, pyelonephritis, interstitial nephritis, tubulointerstitial nephritis, chronic nephritis, acute nephritis, minimal change disease, focal segmental glomerulosclerosis, (m) sympathetic ophthalmia, (n) skin, kidney, heart, lung, pancreas, liver, blood cell, bone marrow, cornea, accidental severed limb, fingers, hand, foot, face, nose, bone, cardiac valve, blood vessel or intestine transplant rejection reaction, (o) Corticobasal degeneration, progressive supranuclear palsy, schizophrenia, inherited Kreutzfeld Jacob, motor neurone disease, spinocerebellar ataxia/atrophie, dementia, frontotemporal dementia, dementia with lewy bodies, multiple system atrophy, hereditary spastic paraparesis, Friedreich's ataxiea, Charcot Marie toot, and (p) a metabolic disease, metabolic disorders of the carbohydrate metabolism, glycogen storage disease, disorders of amino acid metabolism, phenylketonuria, maple syrup urine disease, glutaric acidemia type 1, urea Cycle Disorder or urea Cycle Defects, carbamoyl phosphate synthetase I deficiency, disorders of organic acid metabolism (organic acidurias), alcaptonuria, disorders of fatty acid oxidation and mitochondrial metabolism, medium-chain acyl-coenzyme A dehydrogenase deficiency (MCADD.), disorders of porphyrin metabolism, acute intermittent porphyria, disorders of purine or pyrimidine metabolism, Lesch-Nyhan syndrome, Disorders of steroid metabolism, lipoid congenital adrenal hyperplasia, or congenital adrenal hyperplasia, disorders of mitochondrial function, Kearns-Sayre syndrome, disorders of peroxisomal function, Zellweger syndrome, or lysosomal storage disorders, Gaucher's disease and Niemann Pick disease. |
