Compositions and methods for increasing telomerase activity

摘要

The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.

主权项

1. A method of increasing telomerase activity in a cell or tissue comprising contacting said cell or tissue with an isolated compound of formula I: wherein X1 , is selected from keto, hydroxy, and wherein X2 is selected from keto, hydroxy, and wherein X3 is selected from keto, hydroxy, and wherein at least one of X1, X2, and X3 are respectively; wherein R1 or R2 are independently selected from —CH(CH3)2, and —CH(CH3)CH2CH3 and pharmaceutically acceptable salts thereof, wherein the cell or tissue is identified as requiring increased telomerase activity to treat or prevent a condition or disease in a subject.