Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use

摘要

Pyrazolo[1,5-a]pyrimidine-based compounds of the formula:;
are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.

主权项

1. A compound of the formula:or a pharmaceutically acceptable salt thereof, wherein:
X is CH or N; each R1A is independently —OR1C, —N(R1C)2, —C(O)R1C, —C(O)OR1C, —C(O)N(R1C)2, —N(R1C)C(O)OR1C, cyano, halo, or optionally substituted C1-12 hydrocarbyl or 2-12-membered heterocarbyl, which optional substitution is with one or more R1B; each R1B is independently —OR1C, —N(R1C)2, —C(O)R1C, —C(O)OR1C, —C(O)N(R1C)2, —N(R1C)C(O)OR1C, cyano or halo; each R1C is independently hydrogen or optionally substituted C1-12 hydrocarbyl or 2-12-membered heterocarbyl, which optional substitution is with one or more of cyano, halo or hydroxyl; each R2C is independently —OR2D, —N(R2D)2, —C(O)R2D, —C(O)OR2D, —C(O)N(R2D)2, —N(R2D)C(O)OR2D, cyano, halo, or optionally substituted C1-12 hydrocarbyl or 2-12-membered heterocarbyl, which optional substitution is with one or more amino, cyano, halo, hydroxyl, or R2D; each R2D is independently hydrogen or optionally substituted C1-12 hydrocarbyl or 2-12-membered heterocarbyl, which optional substitution is with one or more of amino, cyano, halo, or hydroxyl; and m is 0-3.