发明名称 |
USE OF IL-12 AND IL-12 ANTAGONISTS for the manufacture of a pharmaceutical composition for THE TREATMENT OF AUTOIMMUNE DISEASES |
摘要 |
<p>Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN- gamma or TNF- alpha . Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.</p> |
申请公布号 |
EP0750509(B2) |
申请公布日期 |
2006.06.14 |
申请号 |
EP19950912666 |
申请日期 |
1995.03.07 |
申请人 |
GENETICS INSTITUTE, LLC |
发明人 |
LEONARD, JOHN P.;GOLDMAN, SAMUEL;O'HARA, RICHARD, JR. |
分类号 |
A61K38/00;A61K38/20;A61K39/395;A61P3/08;A61P3/10;A61P25/00;A61P27/02;A61P37/00;C07K14/54;C07K16/24;C12P21/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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