发明名称 |
CAMPTOTHECIN-CELL PENETRATING PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
摘要 |
The present invention relates to a novel compound of use in the improved delivery of therapeutic drug agents into target cells or tissues, composition comprising the same and uses thereof. The compound is more specifically a conjugate of a peptidic moiety and a camptothecin, a derivative or analog thereof which provides numerous benefits, including enhancement in terms of aqueous solubility, pharmacokinetics and tissue distribution, enlargement of the therapeutic index, and limitation of the inter-patient metabolic variability, as well as improvement of delivery of the biologically active ingredient to the target cells or tissues. |
申请公布号 |
WO2007113687(A3) |
申请公布日期 |
2008.04.24 |
申请号 |
WO2007IB01697 |
申请日期 |
2007.03.30 |
申请人 |
DIATOS S.A.;MICHEL, MATTHIEU;RAVEL, DENIS;RIBES, FABIEN;TRANCHANT, ISABELLE |
发明人 |
MICHEL, MATTHIEU;RAVEL, DENIS;RIBES, FABIEN;TRANCHANT, ISABELLE |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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