| 摘要 |
The present invention relates to improved methods for making and using hemostatic, bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyether, polyacids, polyalkylene oxides, and optionally including multivalent cations and/or polycations and/or hemostatic agents. The polymer s can be associated with each other, and are then either dried into membranes or sponges, or are used as fluids, gels, or foams. Hemostatic, bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent bleeding and the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. The hemostatic, anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and/or physical properties of such compositions can be vari ed as needed by carefully adjusting the pH, solids content cation content of th e polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by adding hemostatic agents. Hemostatic membranes, gels and/ or foams can be used concurrently. Hemostatic, antiadhesion compositions may al so be used to lubricate tissues and/or medical instruments, and/or deliver drug s to the surgical site and release them locally.
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