Combination use of gemcitabine and tumor suppressor gene therapy in the treatment of neoplasms

摘要

This invention describes novel methods of treating subjects afflicted with hyperproliferative diseases such as tumors or metastatic disease. In particular, this invention provides methods of treating cancer, comprising the use of gemcitabine in combination with a tumor suppressor gene or gene product. The invention also provides for a pharmacological composition comprising a tumor suppressor protein or a tumor suppressor nucleic acid and gemcitabine, and a kit for the treatment of mammalian cancer or hyperproliferative cells.