发明名称 |
Derivatives of Variolin B |
摘要 |
The invention provides antitumour compounds of formula (I), wherein R<SUP>1 </SUP>is an aromatic substituent; R<SUP>2 </SUP>is hydrogen or a substituent when the dotted line is absent, or R<SUP>2 </SUP>is absent when the dotted line represents a bond to give a double bond between the nitrogen which bears R<SUP>2 </SUP>and the carbon which bears R<SUP>3</SUP>; R<SUP>3 </SUP>is an oxo group =0 when the dotted line is absent or is a substituent when the dotted line represents a bond to give a double bond between the nitrogen bearing R<SUP>2 </SUP>and the carbon bearing R<SUP>3</SUP>; R<SUP>4 </SUP>is hydrogen or a substituent; and pharmaceutically acceptable salts thereof.
|
申请公布号 |
US2008033001(A1) |
申请公布日期 |
2008.02.07 |
申请号 |
US20070829379 |
申请日期 |
2007.07.27 |
申请人 |
UNIVERSIDAD DE BARCELONA |
发明人 |
ALVAREZ MERCEDES;PUENTES JOSE L.F.;BLEDA DAVID F. |
分类号 |
A61K31/505;A61K31/519;A61K45/00;A61P35/00;C07D471/14 |
主分类号 |
A61K31/505 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|