The present invention relates to a process of preparing a multimeric protein structure comprising at least two ±-galactosidase monomers being covalently linked to one another via a linking moiety, wherein said linking moiety is not present in native ±-galactosidase, the process comprising reacting ±-galactosidase with a cross-linking agent which comprises said linking moiety and at least two reactive groups.
申请公布号
EP3088514(A1)
申请公布日期
2016.11.02
申请号
EP20160173953
申请日期
2011.03.02
申请人
PROTALIX LTD.
发明人
SHULMAN, AVIDOR;RUDERFER, ILYA;BEN-MOSHE, TEHILA;SHEKHTER, TALIA;AZULAY, YANIV;SHAALTIEL, YOSEPH;KIZHNER, TALI