ANTI-TISSUE FACTOR MONOCLONAL ANTIBODY

摘要

Monoclonal antibodies against human and mouse tissue factor, and fragments thereof, are disclosed, as well as pharmaceutical compositions and compositions for drug delivery containing the same. Therapeutic methods using the same are also disclosed.

主权项

1. A monoclonal antibody or biologically active fragment thereof, which binds to tissue factor, selected from the group consisting of:
an anti-human tissue factor monoclonal antibody or biologically active fragment thereof including a heavy chain variable region having complementarity determining regions 1, 2, and 3 containing the amino acid sequences set forth in SEQ ID NOS: 3, 4, and 5, respectively, and a light chain variable region having complementarity determining regions 1, 2, and 3 containing the amino acid sequences set forth in represented by SEQ ID NOS: 6, 7, and 8, respectively; an anti-human tissue factor monoclonal antibody or biologically active fragment thereof including a heavy chain variable region having complementarity determining regions 1, 2, and 3 containing the amino acid sequences set forth in represented by SEQ ID NOS: 11, 12, and 13, respectively, and a light chain variable region having complementarity determining regions 1, 2, and 3 containing the amino acid sequences set forth in represented by SEQ ID NOS: 14, 15, and 16, respectively; and an anti-mouse tissue factor monoclonal antibody or biologically active fragment thereof including a heavy chain variable region having complementarity determining regions 1, 2, and 3 containing the amino acid sequences set forth in SEQ ID NOS: 19, 20, and 21, respectively, and a light chain variable region having complementarity determining regions 1, 2, and 3 containing the amino acid sequences set forth in SEQ ID NOS: 22, 23, and 24, respectively.