| 摘要 |
The present invention has an object to provide a method of screening a compound capable of inhibiting the activities of the disease-associated gene product, compounds obtainable by the screening method, etc. The compounds or a salt thereof that inhibits the activity of the protein having an amino acid sequence identical or substantially identical with the amino acid sequence represented by SEQ ID NO: 1, or a neutralizing antibody that inhibits the activity of that protein may be used as a prophylactic and/or therapeutic agent for various diseases, for example, pulmonary/thoracic diseases and respiratory diseases accompanied by pulmonary/airway inflammation [e.g. chronic obstructive pulmonary diseases (such as chronic bronchitis, pulmonary emphysema, diffuse panbronchiolitis, intrinsic asthma), bronchial asthma, cystis fibrosis, hypersensitivity pneumonitis, pulmonary fibrosis, etc.], inflammatory bowel diseases, allergic conjunctivitis, and so on.
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