1H-imidazole derivatives as cannabinoid CB2 receptor modulators

摘要

The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid CB₂ receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which cannabinoid CB₂ receptors are involved. The compounds have the general formula (I) wherein R₁-R₄ have the meanings given in the specification.