Method for manufacturing block copolymer

摘要

Providing a method for producing a compound represented by formula (1) from a compound represented by formula (2), by which the additive amount of an aryl (C1-C8) alkyl alcohol which may have a substituent and the amount of residual carboxyl groups of pAsp (polyaspartic acid) are controlled.;A production method including obtaining a compound represented by formula (1) by allowing a compound represented by formula (2) to react with an aryl (C1-C8) alkyl alcohol which may have a substituent, and a carbodiimide-based compound in an amount of 2(x+y) equivalents or more relative to the amount of carboxyl groups in formula (2) (sum of x and y), in a solvent at 15° C. to 30° C. for 2 hours to 48 hours, is used.

主权项

1. A method for producing a block copolymer represented by the following formula (1):wherein R1 represents a hydrogen atom or a (C1-C5) alkyl group; R2 represents a (C1-C5) alkylene group; R3 represents a methylene group or an ethylene group; R4 represents a hydrogen atom or a (C1-C4) acyl group; R5 represents (i) a hydroxyl group, (ii) an aryl (C1-C8) alkoxy group optionally substituted with one or more members selected from the group consisting of a methoxy group, an ethoxy group, an isopropoxy group, an n-butoxy group, a t-butoxy group, a fluorine atom, a chlorine atom and a bromine atom, a nitro group, and a cyano group, or (iii) —N(R6)-CO—NHR7 (wherein R6 and R7, which may be identical with or different from each other, each represent a (C3-C6) cyclic alkyl group, or a (C1-C5) alkyl group which may be substituted with a tertiary amino group); n represents 20 to 500; m represents 2 to 200; a represents 0 to 100; b represents 0 to 100, provided that the sum of a and b is greater than or equal to 1 and not greater than m; the proportion of R5 representing a hydroxyl group is 0% to 5% of m; the proportion of R5 representing an aryl (C1-C8) alkoxy group which may have a substituent is 10% to 80% of m; and the proportion of R5 representing —N(R6)-CO—NHR7 is 11% to 30% of m,
the method comprising allowing a compound represented by the following formula (2):wherein R1 represents a hydrogen atom or a (C1-C5) alkyl group; R2 represents a (C1-C5) alkylene group; R3 represents a methylene group or an ethylene group; R4 represents a hydrogen atom or a (C1-C4) acyl group; n represents 20 to 500; x represents 0 to 100; and y represents 0 to 100, provided that the sum of x and y is 2 to 200,
to react with an aryl (C1-C8) alkyl alcohol which may have a substituent, and a carbodiimide-based compound in an amount of 2(x+y) equivalents or more relative to the amount of carboxyl groups in formula (2) (sum of x and y) in a solvent at 22° C. to 27° C. for 2 hours to 48 hours in a one-pot, one-stage process.