发明名称 |
Polysaccharides comprising two antithrombin III-binding sites, preparation thereof and use thereof as antithrombotic medicaments |
摘要 |
The invention relates to sulphated polysaccharides which have the general structure of the constituent polysaccharides of heparin and which have a molecular weight of less than 8000 Daltons, comprising two antithrombin III-binding hexasaccharide sequences corresponding to formula (I) in which: R1 represents an OH group when the hexasaccharide of formula (I) is located at the reducing end of the polysaccharide, or else R1 represents a bond with another saccharide unit of said polysaccharide; R2 represents a hydrogen atom when the hexasaccharide of formula (I) is located at the non-reducing end of the polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit of said hexasaccharide is a double bond, or else R2 represents a bond with another saccharide unit of said polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit is a single bond. Preparation thereof, use thereof as antithrombotic medicaments, and also use thereof in a method for analyzing a sample of a heparin derivative.; |
申请公布号 |
US9346894(B2) |
申请公布日期 |
2016.05.24 |
申请号 |
US201214111300 |
申请日期 |
2012.04.11 |
申请人 |
SANOFI |
发明人 |
Mourier Pierre;Viskov Christian |
分类号 |
C08B37/00;A61K31/727;G01N30/86;B01D15/34;B01D15/36;B01D15/38;A61K45/06;B01D15/18 |
主分类号 |
C08B37/00 |
代理机构 |
Scully Scott Murphy and Presser |
代理人 |
Scully Scott Murphy and Presser |
主权项 |
1. A sulfonated polysaccharide having a polysaccharide of heparin which has a molecular weight of less than 8000 Daltons, said sulfonated polysaccharide comprising two antithrombin III-affinity sites, wherein said polysaacharide is in isolated form. |
地址 |
Paris FR |