CD37-binding molecules and immunoconjugates thereof

摘要

Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to CD37 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.

主权项

1. A method for inhibiting the growth of a cell expressing CD37 comprising contacting the cell with an antibody or antigen binding fragment thereof that specifically binds to CD37, wherein said antibody or fragment thereof comprises a heavy chain variable region and a light chain variable region, wherein the CDR1, CDR2, and CDR3 of said heavy chain variable region and the CDR1, CDR2, and CDR3 of said light chain variable region comprise the polypeptide sequences:
SEQ ID NOs: 4, 5, and 6 and SEQ ID NOs: 28, 29, and 30, respectively.