| 摘要 |
599334 Disclosed herein are methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. In one embodiment a compound of formula (I) is prepared by treating spiro[furo[2,3-f][1,3]benzodioxole-7,3’-indol]-2’(1’H)-one with 2-bromomethyl-5-(trifluoromethyl)furan. In another embodiment a compound of formula (II) is prepared by treating 2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3’-indol]-2’(1’H)-one with 2-(chloromethyl)-3-(trifluoromethyl)pyridine hydrochloride. |
