DIMETHYLAMINO GLAUCOCALYXIN A HYDROCHLORIDE SALT AND CRYSTALLINE FORM THEREOF

摘要

Disclosed is a glaucocalyxin A derivative -- dimethylamino glaucocalyxin A hydrochloride salt -- and two crystalline forms thereof. The dimethylamino glaucocalyxin A hydrochloride salt provided by the present invention has good water solubility and high oral bioavailability; the two crystalline forms of the dimethylamino glaucocalyxin A hydrochloride salt are readily soluble in water, reducing the time required for dissolving and decreasing product degradation; the invention is not prone to produce electrostatic charges, which is advantageous to the preparation of subsequent formulation products; futhermore, the filtration operation during the process of preparation is simple, the product is easy to dry, and the properties of the crystal are stable during drying; the purification effect during the preparation process is obvious, crystal purity is high, and the invention is suitable for industrial production.