Method and system for ABO antibody detection and characterization
摘要
The present application discloses a system and method for ABO antibody detection and characterization that can provide an alternative means for assessment and management of ABO-incompatible and ABO- compatible transplants. The method and system comprises determining an anti-ABO blood group antigen subtype antibody profile of a subject using a biological sample from the subject. The method and system can be used to evaluate the suitability of a donor blood or tissue product for a recipient subject by comparing the determined anti-ABO antigen subtype antibody profile of the recipient subject with the ABO histo- blood group or ABO histo-blood subgroup of a donor blood or tissue product. In order to define the subject's ABO histo-blood subgroup, the determined antibody profile is compared to known ABO histo- blood group antigen subtype profiles and/or known anti-ABO antigen subtype antibody profiles for ABO histo-blood subgroups to identify the ABO histo-blood subgroup of the subject. Profiles can be established by applying a sample to an array of surface-bound ABO antigens selected from the group of type I to type VI antigens of each blood group A, B or H.
申请公布号
AU2012304181(B2)
申请公布日期
2016.11.24
申请号
AU20120304181
申请日期
2012.08.30
申请人
The Governors of the University of Alberta
发明人
Lowary, Todd Lambert;Cairo, Christopher Warren;West, Lori Jeanne;Buriak, Jillian Mary;Meloncelli, Peter John;Jeyakanthan, Mylvaganam;Slaney, Anne Margaret