发明名称 |
IMMUNOLOGIC ACTIVITY MEASURE(S) FOR T HELPER ON-ASSOCIATED CONDITIONS |
摘要 |
A method of providing a reproducible and clinically relevant disease activity measurement for a group of immunologic disorders that share features of a T "helper" 1 (Th1) immune activation phenotype is disclosed. Th1 responses are characterized by the release of a set of pro-inflammatory substances by white blood cells (WBC) By evaluating the ex vivo activation response of whole blood in terms of the extent of release of Th1 produced pro-inflammatory substances in blood (i.e., WBC activity) following activation with a Th1-associated stimulant, the level of, e.g., disease activity or immunosuppression in a specific individual can be determined. The method of the invention provides a disease activity marker for a wide variety of Th1 inflammatory responses, including Crohn's Disease, psoriasis, rheumatoid arthritis, Systemic Lupus Erythematosus (SLE), multiple sclerosis and solid organ transplant rejection. |
申请公布号 |
WO2005016954(A2) |
申请公布日期 |
2005.02.24 |
申请号 |
WO2004US26236 |
申请日期 |
2004.08.10 |
申请人 |
BOSTON MEDICAL CENTER CORPORATION;SAUBERMANN, LAWRENCE, J.;FARRAYE, FRANCIS, A.;MORALES, VICTOR, M. |
发明人 |
SAUBERMANN, LAWRENCE, J.;FARRAYE, FRANCIS, A.;MORALES, VICTOR, M. |
分类号 |
C07K;C12Q1/02;G01N33/50;G01N33/53 |
主分类号 |
C07K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|