A self-inactivating recombinant lentiviral vector for the inhibition of HIV replication

摘要

The present invention refers to a self-inactivating recombinant lentiviral vector comprising a 5' LTR and a 3' LTR, wherein the LTR region has been rendered substantially transcriptionally inactive by virtue of deletions in the U3 region of the 3' LTR, characterized in that the lentiviral vector is further comprising a beta-interferon gene positioned under the control of a promoter.