| 摘要 |
PROBLEM TO BE SOLVED: To provide a porphyrin compound useful as an anti-oxidant that can exhibit high anti-oxidation capability only to the location of high reactive oxygen species (ROS) in a living body, and that is useful as a drug delivery composition.SOLUTION: The porphyrin compound A in figure 1 has a high lipid solubility, and therefore can permeate through blood-brain barrier and cell membrane. Since there are abundance of reactive oxygen species in cell, a sulfide group is oxidized and becomes sulfoxide B having a high antioxidation power. Because the sulfoxide B has a lowered lipid solubility, and stays within the cell, and as a result, the porphyrin compound as an antioxidant stays at the location where there are abundance of ROS and an antioxidation power is needed.SELECTED DRAWING: Figure 1 |
