Identification and Attenuation of the Immunosuppressive Domains in Fusion Proteins of Enveloped RNA Viruses

摘要

The present invention relates to enveloped RNA viruses. The invention in particular relates to the generation of superior antigens for mounting an immune response by first identifying then mutating the immunosuppressive domains in fusion proteins of enveloped RNA viruses resulting in decreased immunosuppressive properties of viral envelope proteins from the viruses.

主权项

1. A mutated peptide providing reduced immunosuppressive properties, said mutated peptide comprising a mutated sequence selected from SEQ ID NOS:201-203 or a variant of an amino acid sequence selected from the sequences shown in Table 1 or selected from SEQ ID NOS:1-200, wherein said mutated sequence comprises from 1 to 4 amino acid substitutions, or at least one amino acid insertion, or at least one amino acid deletion.