PRODRUGS FOR THE ORAL AND PARENTERAL DELIVERY OF AMINE-CONTAINING DRUGS, AMINO ACIDS, AND PEPTIDES
摘要
Compounds and compositions for prodrugs useful for the oral and parenteral delivery of amine-containing drugs, amino acids, and peptides are described. Compounds containing biologically-active amino groups are conjugated to a lipophilic derivative through an amide bond in order to facilitate transport of the conjugate through the cell membrane. Methods of coupling a biologically-active molecule containing at least one amine functional group to a lipophilic anhydride are also described.
申请公布号
WO2005016260(A2)
申请公布日期
2005.02.24
申请号
WO2004US24109
申请日期
2004.07.26
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;GEE, KELVIN, W.;WANG, JINGHUA, J.;HOGENKAMP, DERK, J.
发明人
GEE, KELVIN, W.;WANG, JINGHUA, J.;HOGENKAMP, DERK, J.