AQUEOUS BASED PHARMACEUTICAL FORMULATIONS OF WATER-SOLUBLE PRODRUGS OF PROPOFOL
摘要
The present invention is directed to aqueous based formulations of water-soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water-soluble prodrug of propofol in the absence of an antioxidant. The formulations are particularly useful as intravenous injections. The formulations preferably are buffered to a pH suitable for minimizing degradation of the prodrug during storage. The formulations can be prepared without the use of harmful co-solvents or surfactants and are stable at room temperature over extended periods of time.
申请公布号
WO2008045189(A2)
申请公布日期
2008.04.17
申请号
WO2007US20351
申请日期
2007.09.20
申请人
MGI GP, INC.;PATEL, KANAIYALAL, R.;DORDUNOO, STEPHEN;KELLER, DAVID
发明人
PATEL, KANAIYALAL, R.;DORDUNOO, STEPHEN;KELLER, DAVID