发明名称 |
ANTI-ICOS ANTIBODIES AND THEIR USE IN TREATMENT OF ONCOLOGY, TRANSPLANTATION AND AUTOIMMUNE DISEASE |
摘要 |
The present invention provides anti-human ICOS antibodies with increased effector function. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human ICOS antigen and that may mediate ADCC, CDC, and/or antibody-dependent phagocytosis (opsonisation) for the treatment and prevention of T cell-mediated diseases and disorders, such as, but not limited to, chronic infection, autoimmune disease or disorder, inflammatory disease or disorder, graft-versus-host disease (GVHD), transplant rejection, and T cell proliferative disorder. |
申请公布号 |
WO2008137915(A3) |
申请公布日期 |
2009.01.08 |
申请号 |
WO2008US62859 |
申请日期 |
2008.05.07 |
申请人 |
MEDIMMUNE, LLC;COYLE, ANTHONY;YAO, YIHONG;JALLAL, BAHIJA;CARLESSO, GIANLUCA;BOWEN, MICHAEL |
发明人 |
COYLE, ANTHONY;YAO, YIHONG;JALLAL, BAHIJA;CARLESSO, GIANLUCA;BOWEN, MICHAEL |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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