| 摘要 |
PROBLEM TO BE SOLVED: To provide genetically-modified donor animals, tissues, and cells.SOLUTION: The present invention provides certain animals, and in particular porcine animals, tissue and cells derived from these, which lack any expression of functional α1,3 galactosyltransferase (αGT) and express one or more additional transgenes which make them suitable donors for pancreatic islet xenotransplantation. Methods of treatment and prevention of diabetes using cells derived from such animals are also provided. In a particular embodiment, the transgene specifically expressed in pancreatic tissue is at least one anti-coagulant. In another particular embodiment, the transgene specifically expressed in pancreatic tissue is at least one immunomodulator. In specific embodiment, the transgene specifically expressed in pancreatic tissue is at least one immunosuppressant. In a further particular embodiment, the transgene specifically expressed in pancreatic tissue is at least one cytoprotective transgene.SELECTED DRAWING: None |
