| 发明名称 |
IMMUNOGENIC POLYPEPTIDES COMPRISING A SCAFFOLD POLYPEPTIDE AND A L2 POLYPEPTIDE OR A FRAGMENT THEREOF |
| 摘要 |
The present invention relates to an immunogenic polypeptide comprising a) a scaffold polypeptide, and b) a L2 polypeptide or a fragment of said L2 polypeptide, wherein said scaffold polypeptide constrains the structure of said L2 polypeptide, or of a fragment of said L2 polypeptide. Moreover, the present invention relates to a vaccine comprising said immunogenic polypeptide. The present invention is also concerned with a method for producing an antibody against human papillomavirus. Also encompassed by the present invention is an antibody obtained by carrying out the said method. |
| 申请公布号 |
US2016250316(A1) |
申请公布日期 |
2016.09.01 |
| 申请号 |
US201615051370 |
申请日期 |
2016.02.23 |
| 申请人 |
DKFZ Deutsches Krebsforschungszentrum |
发明人 |
MUELLER Martin;RUBIO Ivonne;TOMMASINO Massimo;OTTONELLO Simone;BOLCHI Angelo |
| 分类号 |
A61K39/12;C07K16/08;C12N7/00;C07K14/005;A61K39/385 |
主分类号 |
A61K39/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An immunogenic polypeptide comprising
a) a scaffold polypeptide, and b) a L2 polypeptide comprising an amino acid sequence as shown in SEQ ID NO:1, or a fragment thereof, wherein said scaffold polypeptide constrains the structure of said L2 polypeptide, or of said fragment of said L2 polypeptide. |
| 地址 |
Heidelberg DE |
