| 发明名称 |
BIOACTIVE GAS-ENCAPSULATED ECHOGENIC LIPOSOMES AND METHODS FOR TREATING CARDIOVASCULAR DISEASE |
| 摘要 |
Echogenic liposomes (ELIP) formulated with an at least partially pegylated phospholipid bi-layer shell, encapsulated nitric oxide, and encapsulated perfluorocarbon of the formula CxFy in a ratio of about 1:1 by volume, wherein X is greater than or equal to 3, are disclosed, along with methods for treating a patients suffering from cardiovascular disease by administering the ELIP at a site remote from the target diseased section, monitoring presence of the ELIP at the target diseased section, and administering ultrasound upon detection of presence such that bioactive NO is released at the target diseased section. |
| 申请公布号 |
US2016250252(A1) |
申请公布日期 |
2016.09.01 |
| 申请号 |
US201514957705 |
申请日期 |
2015.12.03 |
| 申请人 |
University of Cincinnati |
发明人 |
Holland Christy;Raymond Jason;Sutton Jonathan |
| 分类号 |
A61K33/00;A61M37/00;A61K41/00;G01N33/50;A61K9/127;A61K9/00 |
主分类号 |
A61K33/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating a patient suffering from cardiovascular disease, the method comprising: delivering a liposome comprising nitric oxide (NO) locally to a target diseased section of the patient's vasculature; and releasing the NO at the target diseased section, wherein the liposome comprises NO in a ratio of from about 2:1 to about 1:2 by volume with a perfluorocarbon. |
| 地址 |
Cincinnati OH US |
