CARBOXYMETHYLCELLULOSE POLYETHYLENE GLYCOL COMPOSITIONS FOR MEDICAL USES

摘要

Compositions and method of manufacturing carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, the functional groups of a bi-functional PEG molecule (PEG diglycidyl ether) are attached to different CPSs, thereby forming a covalently cross-linked composition. Such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles, and lubricants of tissues and medical instruments.

主权项

1. A biologically compatible PEG/CMC composition, comprising:
a carboxymethyl cellulose (CMC) having an average molecular weight of about 700 kD (CMC-A) and a degree of substitution of about 0.65 to 0.85; and a polyethylene glycol di-epoxide (PEG diglycidyl ether (PEGDGE)) having a molecular weight between about 500 Daltons and about 8000 Daltons, said PEG linked to said CMC-A via an addition reaction of one of said epoxide moieties of said PEGDGE to a carboxyl or an alcohol moiety of one molecule of CMC-A, and the other of said epoxide moieties of said PEGDGE to a carboxyl or an alcohol moiety of another molecule of CMC-A, forming a cross-linked PEG/CMC-A composition having a carboxymethyl anhydroglucose unit (CMAG) to epoxide (EP) ratio of between about 0.5 and about 30.