| 发明名称 |
FORMULATION OF ACOUSTICALLY ACTIVATABLE PARTICLES HAVING LOW VAPORIZATION ENERGY AND METHODS FOR USING SAME |
| 摘要 |
Acoustically activatable particles having low vaporization energy and methods for making and using same are disclosed. A particle of material includes a first substance that includes at least one component that is a gas 25° C. and atmospheric pressure. A second substance, different from the first substance, encapsulates the first substance to create a droplet or emulsion that is stable at room temperature and atmospheric pressure. At least some of the first substance exists in a gaseous phase at the time of encapsulation of the first substance within the second substance to form a bubble. After formation of the bubble, the bubble is condensed into a liquid phase, which causes the bubble to transform into the droplet or emulsion having a core consisting of a liquid. The droplet or emulsion is an activatable phase change agent that remains a droplet having a core consisting of a liquid at 25° C. and atmospheric pressure. The first substance has a boiling point below 25° C. at atmospheric pressure. |
| 申请公布号 |
US2016361447(A1) |
申请公布日期 |
2016.12.15 |
| 申请号 |
US201615247840 |
申请日期 |
2016.08.25 |
| 申请人 |
The University of North Carolina at Chapel Hill ;The Arizona Board of Regents on behalf of the University of Arizona ;The Regents of the University of Colorado, a body corporate |
发明人 |
Dayton Paul A.;Sheeran Paul S.;Matsunaga Terry O.;Borden Mark A. |
| 分类号 |
A61K49/22;A61K47/06;A61K9/51;A61K41/00 |
主分类号 |
A61K49/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A particle of material, comprising:
a first substance that includes at least one component that is a gas 25° C. and atmospheric pressure; and a second substance, different from the first substance, that encapsulates the first substance to create a droplet or emulsion that is stable at room temperature and atmospheric pressure, wherein at least some of the first substance exists in a gaseous phase at the time of encapsulation of the first substance within the second substance to form a bubble, and, after formation of the bubble, the bubble is condensed into a liquid phase, which causes the bubble to transform into the droplet or emulsion having a core consisting of a liquid; wherein the droplet or emulsion is an activatable phase change agent that remains a droplet having a core consisting of a liquid at 25° C. and atmospheric pressure, and wherein the first substance has a boiling point below 25° C. at atmospheric pressure. |
| 地址 |
Chapel Hill NC US |
