| 摘要 |
<p>A microfluidic device and its use for the production of micro-arrays, in particular for the detection of protein interactions, is described. Said microfluidic device comprises a flow cell part ( 1 ) and a chip part ( 2 ) together forming at least two crossing, preferably perpendicular, closed channels ( 3, 4 ), said flow cell part forming open channels providing the bottom wall and at least part of the side walls, in particular three walls of said closed channels ( 3, 4 ), said closed channels ( 3, 4 ) being connected to at least three fluid providing means for generating at least three fluid flows ( 7 ) and said closed channels ( 3, 4 ) being designed and dimensioned such that the flow of at least three aqueous fluids streaming through each of said channels ( 3, 4 ) is laminar at least until after said crossing of said channels ( 6 ), said chip part ( 2 ) forming the top wall and optionally part of said side walls, in particular the fourth wall, of said closed channels ( 3, 4 ) and having a surface that is activatable by reaction with an activating molecule.</p> |
