| 摘要 |
The present invention is directed towards an improved, five step method for the preparation of the anti-epileptic drug (R)-Lacosamide, as illustrated in Fig. 2. The active form of the drug is (R)-enantiomer and the present method gives high yields of (R)-enantiomer of lacosamide. The method does not involve use of any unnatural amino acids as starting material or use of protection/deprotection strategies, strong acids or hydrogenation. Instead, the method uses a cheap and easily available racemic butadiene monoepoxide as the starting material. |
