发明名称 |
NOVEL ANTI-IL 13 ANTIBODIES AND USES THEREOF |
摘要 |
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis. |
申请公布号 |
WO2005062967(A3) |
申请公布日期 |
2006.12.21 |
申请号 |
WO2004US43501 |
申请日期 |
2004.12.23 |
申请人 |
TANOX, INC.;FUNG, SEK, CHUNG;MOYLE, MATTHEW;LU, MASON;YAN, CHANGNING;SINGH, SANJAYA;HUANG, DAN |
发明人 |
FUNG, SEK, CHUNG;MOYLE, MATTHEW;LU, MASON;YAN, CHANGNING;SINGH, SANJAYA;HUANG, DAN |
分类号 |
C12Q1/70;A61K38/00;A61K39/395;C07H21/02;C07H21/04;C07K2/00;C07K4/00;C07K5/00;C07K7/00;C07K14/00;C07K16/00;C07K16/24;C07K17/00;G01N33/53 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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