COMPOSITIONS COMPRISING MODIFIED LCAT AND USES THEREOF

摘要

The invention provides compounds, pharmaceutical compositions and methods comprising modified LCAT for treating atherosclerosis, inflammation, thrombosis and other conditions and for decreasing or prevention of accumulation of cholesterol in a subject. The modified LCAT having a replacement of the amino acid residue 31 by a cysteine residue. The cysteine residue being modified by replacing the thiol hydrogen with 3-pyrazinyl-2-carbonitrile.