HYDROPHILIC COATING FOR INTRAVASCULAR DEVICES

摘要

The present disclosure relates to a coating for medical devices. The lubricious coating includes a primer layer and a top coating layer as well as methods of making and using the same. The primer layer includes a reaction cured product of a multifunctional acrylate and an acid functionalized monoacrylate. The top coating layer includes a reaction cured product of a mixture that includes a hydrophilic polymer comprising polyvinylpyrrolidone, an acid functionalized monoacrylate, and a hydrophilic monomer. The lubricious coating may be coated onto medical devices to form a sensing guide wire, an ultrasound imaging device, and an intravascular imaging device. Associated devices and methods are also provided.

主权项

1. An intravascular device, comprising:
a flexible elongate member, wherein at least a portion of the flexible elongate member includes an outer coating, the outer coating comprising: a primer layer comprising the reaction cured product of a first mixture comprising:
a multifunctional acrylate,a first acid functionalized monoacrylate, anda first polymerization initiator; and a top coating layer comprising a reaction cured product of a second mixture comprising:
a hydrophilic polymer comprising polyvinylpyrrolidone,a second acid functionalized monoacrylate,a hydrophilic monomer, anda second polymerization initiator; wherein the top coating layer is in contact with the primer layer and is an outermost layer of the coating.