发明名称 |
PHARMACEUTICAL PREPARATION CONTAINING CRYSTALLINE FORM I OR II OF 5-AMINO-2,3-DIHYDROPHTHALAZINE-1,4-DIONE SODIUM SALT |
摘要 |
PROBLEM TO BE SOLVED: To provide a novel crystal of 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt that is a pharmaceutical preparation for treating an inflammatory disease in which a symptom caused by an excessive immune response.SOLUTION: A pharmaceutical preparation contains the crystalline forms I and II of 5-amino-2,3-dihydrophthalazine-1,4-dione alkali salt, and has the crystallography values determined by means of x-ray powder diagrams, form I: d values: 13.5; 6.9; 5.2; 4.6; 3.9; 3.5; 3.4; 3.3; 3.1; 3.0 and 2-θ values: 6.5; 12.7; 16.9; 19.3; 22.8; 25.8; 26.6; 27.2; 28.7; 30.3, and form II: d values: 12.9; 7.9; 7.1; 6.5; 5.3; 4.0; 3.7; 3.6; 3.3; 3.2 and 2-θ values: 6.8; 11.2; 12.5; 13.7; 16.7; 22.4; 24.3; 24.9; 27.2; 27.8.SELECTED DRAWING: None |
申请公布号 |
JP2016196483(A) |
申请公布日期 |
2016.11.24 |
申请号 |
JP20160115125 |
申请日期 |
2016.06.09 |
申请人 |
METRIOPHARM AG |
发明人 |
JOSEF BREU;WOLFGANG BRYSCH;ASTRID KAISER;BEATE LUDESCHER;GERRIT MAASS;THOMAS MARTIN;WOLFGANG MILIUS;MICHAEL NIEDERMAIER |
分类号 |
A61K31/502;A61P1/04;A61P5/14;A61P7/00;A61P7/04;A61P9/00;A61P13/02;A61P17/00;A61P17/06;A61P19/02;A61P21/04;A61P25/00;A61P27/02;A61P29/00;A61P31/00;A61P31/04;A61P31/12;A61P31/16;A61P31/18;A61P35/00;A61P35/02;A61P37/00;A61P37/02;A61P37/06 |
主分类号 |
A61K31/502 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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