Use of a Nifie 14 binding substance for the diagnosis and treatment of cancer

摘要

Use of a nucleic acid (I) that encodes a Nifie 14 peptide or protein (II) and/or (II) itself for detecting a cancer, or the risk of developing it, by examining a tissue sample for (over)transcription of Nfie14 RNA or for (over)expression of (II). An independent claim is also included for a peptide or protein containing, or consisting of, a 224 amino acid (aa) sequence (2), reproduced, or fragments of it with at least 4-10 aa; also nucleic acids that encode them, preferably containing a partial sequence, of 12-30 nucleotides, from a sequence of 869 bp (1), reproduced. ACTIVITY : Cytostatic. No details of tests for cytostatic activity are given. MECHANISM OF ACTION : Inhibiting expression or activity of Nifie 14.